PROPIONIBACTERIUM ACNES A RARE CAUSE OF SARCOIDOSIS

Propionibacterium acnes as a Cause of Sarcoidosis

Role of Propionibacterium Acnes in Sarcoidosis: A Meta-analysis.

PURPOSE To evaluate the available molecular evidence on the possible role of Propionibacterium acnes (P. acnes) in the development of sarcoidosis, the meta-analysis was performed. METHODS Case-control studies from January 1980 to October 2012 on P. acnes associated with sarcoidosis were searched.Overall odds ratios (OR) and 95% confidence intervals (CI) were obtained. RESULTS Nine studies w...

Propionibacterium acnes isolated from lymph nodes of patients with sarcoidosis.

Propionibacterium acnes has been repeatedly suggested as a candidate causative agent of sarcoidosis. It is the only microorganism that has been isolated from sarcoid lesions by bacterial culture so far and this has been described in Japanese patients only. We report two non-Japanese patients in whom mediastinoscopy was performed in order to obtain lymph node tissue for histopathology, which was...

Propionibacterium acnes: A Treatable Cause of Constrictive Pericarditis

In this case report we share a case of infective Pericarditis caused by Propionibacterium acnes (P. acnes) in an immune-competent, nonsurgical patient. This case and review will illustrate the importance of considering P. acnes as a cause of idiopathic pericardial effusion and effusive constrictive disease. The patient was a 61-year-old male with history of osteoarthritis of the knee. He receiv...

Alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis patients.

The proliferation of lymphocytes induced by Propionibacterium acnes (P. acnes) was measured by the in vitro incorporation of 3H-thymidine. The mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. The proliferation w...